Comparison of Mo99 Metabolism in Swine and Cattle as Affected by Stable Molybdenum

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Abstract
Data from yearling cattle and growing swine having similar molybdenum, copper and sulfate intakes demonstrated marked species differences in absorption and excretion of Mo99. Mo99 from oral doses reached a peak in blood of swine at 2 to 4 hours, whereas the average time in cattle was 96 hours. Over 75% of both oral and intravenously dosed Mo99 was excreted in urine of swine in 120 hours. In contrast, fecal excretion was the main route of excretion in both oral and intravenous doses in cattle with only 15% excreted in urine in 168 hours by intravenously dosed cattle. Added stable molybdenum increased urinary Mo99 excretion in swine but had little influence on Mo99 excretion in cattle. These data demonstrate a definite species difference and support the differences in toxicity of molybdenum in swine and cattle.