IMMUNOTHERAPEUTIC POTENTIAL IN MURINE TUMOR-MODELS OF POLYINOSINIC-POLYCYTIDYLIC ACID AND POLY-L-LYSINE SOLUBILIZED BY CARBOXYMETHYLCELLULOSE
- 1 January 1985
- journal article
- research article
- Vol. 45 (3) , 1066-1072
Abstract
The systemic administration of multiple, nontoxic doses of polyinosinic-polycytidylic acid and poly-L-lysine solubilized by carboxymethylcellulose [poly(I,C)-LC] eradicated established experimental and spontaneous pulmonary metastases. Optimal immunotherapy was schedule dependent, requiring 3-5 injections of poly(I,C)-LC per week for a minimum of 4 wk; in addition, therapeutic efficiency was partially dosage independent. Immunotherapy by poly(I,C)-LC was limited by tumor burden, although when combined with chemotherapy as a debulking regimen it resulted in increased survival with protocols in which poly(I,C)-LC alone was insufficient. The systemic administration of poly(I,C)-LC may provide a successful adjuvant therapeutic modality against cancer metastasis.This publication has 12 references indexed in Scilit:
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