Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes
- 1 January 1987
- journal article
- Published by Springer Nature in Nature
- Vol. 325 (6100) , 125-130
- https://doi.org/10.1038/325125a0
Abstract
The genes encoding the alpha and beta chains of the T-cell receptor (Ti) of an antigen-specific, Ia-restricted murine T-cell hybridoma were introduced into T3-positive or T3-negative human T cells. The resultant transfectants express either mouse-human or mouse-mouse Ti alpha beta molecules functionally associated with the human T3 complex. Only the complete murine Ti alpha beta dimer mediates specific functional corecognition of the appropriate antigen-Ia pair.Keywords
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