A third type of murine T-cell receptor gene
- 1 November 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 312 (5989) , 31-35
- https://doi.org/10.1038/312031a0
Abstract
By subtractive cDNA [complementary DNA] hybridizations, a new species of T cell receptor cDNA clone whose predicted amino acid sequence has homology to variable, constant, joining and diversity segments of Ig and T cell receptors was isolated. The corresponding genomic sequence was also rearranged in several T cell DNA. The 4 potential N-linked glycosylation sites, frequency of expression and predicted MW (27,800) of this molecule make it a likely candidate for the .alpha.-chain of the T cell receptor. Expression data also indicate that this gene may be activated at a later stage of T cell differentiation than the .beta.-chain.Keywords
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