Genomic organization and sequence of T-cell receptor β-chain constant- and joining-region genes

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Abstract
The genomic structure of the joining (J) and constant (C) regions of the locus encoding the .beta.-chain of the murine T cell receptor was analyzed. The gene segments are arranged tandemly (J-C/J-C) within a 15 kilobase region. The 2 constant-region genes are almost identical, differing by only 4 amino acids, all in carboxy-terminal portions. Each C region comprises 4 exons encoding an external globular domain, a small hinge-like region, a transmembrane region and a cytoplasmic tail plus 3''-untranslated region. The 2 clusters of J regions each contain 7 distinct elements, 12 of which may be functional.