Potential organ- or tumor-imaging agents. 18. Radioiodinated diamines and bisquaternaries

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Abstract
Diamines and their quaternary derivatives were employed as carrier molecules for .gamma.-emitting radiation. The diamine putrescine is widespread in nature and has been reported to selectively concentrate in the rat ventral prostate and pancreas. The selective uptake of radioactivity is confirmed in the rat ventral prostate, but not in the pancreas, following administration of [14C]putrescine. The radioiodinated analogs of putrescine showed no predilection for either of these organs. Radioactivity associated with a radioiodinated quaternary derivatived accumulated in cartilaginous tissues such as trachea, intervertebral disks and chondrosarcoma tumor in a manner similar to hexamethonium.