THE EFFECT OF ABRUPT CHANGES IN PLASMA CALCIUM CONCENTRATIONS ON RENAL FUNCTION AND ELECTROLYTE EXCRETION IN MAN AND MONKEY12

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Abstract
Calcium infusions in man and monkey at the rate of 0.1 mg Ca/minuteAg produce a prompt increase in the rate of Na, Cl and water excretion. Single intravenous administration of 10, 20 and 40 ml of 10% calcium gluconate solution in man produces a comparable increase in the rate of salt and water excretion in proportion to the dose administered. The Ca infusions or single intravenous injections evoke a prompt increase in the rate of P excretion. The effects of a single intravenous injection of Ca are not appreciably modified by the prior acidification or alkalinization of the urine. A reduction in the plasma Ca concentration by the administration of a chelating agent causes a fall in the rate of salt excretion.