Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
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- 19 February 2006
- journal article
- research article
- Published by Springer Nature in Nature Medicine
- Vol. 12 (3) , 301-303
- https://doi.org/10.1038/nm1369
Abstract
Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.Keywords
This publication has 14 references indexed in Scilit:
- Donor Islet Endothelial Cells Participate in Formation of Functional Vessels Within Pancreatic Islet GraftsDiabetes, 2005
- Heart transplantation in baboons using α1,3-galactosyltransferase gene-knockout pigs as donors: initial experienceNature Medicine, 2004
- Reversal of diabetes in non‐immunosuppressed rhesus macaques by intraportal porcine islet xenografts precedes acute cellular rejectionXenotransplantation, 2004
- Islet allograft survival in nonhuman primates immunosuppressed with basiliximab, RAD, and FTY7201Transplantation, 2004
- Efficacy and safety of ABI793, a novel human anti-human CD154 monoclonal antibody, in cynomolgus monkey renal allotransplantation1Transplantation, 2004
- T-Cell–specific immunosuppression results in more than 53 days survival of porcine islets of langerhans in the monkeyTransplantation, 2003
- Cutting Edge: Recipient MHC Class II Expression Is Required to Achieve Long-Term Survival of Murine Cardiac Allografts After Costimulatory BlockadeThe Journal of Immunology, 2001
- Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and ApoptosisThe Journal of Immunology, 2000
- EFFECTS OF LEFLUNOMIDE AND DEOXYSPERGUALIN IN THE GUINEA PIG???RAT CARDIAC MODEL OF DELAYED XENOGRAFT REJECTIONTransplantation, 1997
- Transplantation of porcine fetal pancreas to diabetic patientsThe Lancet, 1994