Elevated Free Fatty Acid Concentrations in Lipemic Sera Reduce Protein Binding of Valproic Acid Significantly More Than Phenytoin
- 1 February 1997
- journal article
- Published by Elsevier in The Lancet Healthy Longevity
- Vol. 313 (2) , 75-79
- https://doi.org/10.1097/00000441-199702000-00001
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- Clinical utility of unbound antiepileptic drug blood levels in the management of epilepsyNeurology, 1992
- Binding Parameters of Valproic Acid to Serum Protein in Healthy Adults at Steady StateTherapeutic Drug Monitoring, 1992
- Alteration of Drug-Protein Binding in Renal DiseaseClinical Pharmacokinetics, 1984
- Effect of low doses of heparin on the plasma binding of phenytoin and prazosin in normal manEuropean Journal of Clinical Pharmacology, 1983
- Free Fraction of Valproic Acid: In Vitro Time‐Dependent Increase and Correlation with Free Fatty Acid Concentration in Human Plasma and SerumEpilepsia, 1983
- Protein Binding of Valproic Acid in the Presence of Elevated Free Fatty Acids in Patient and Normal Human SerumEpilepsia, 1981
- Valproic AcidTherapeutic Drug Monitoring, 1979
- Pharmacokinetics and bioavailability of sodium valproateClinical Pharmacology & Therapeutics, 1977
- Influence of acute renal failure on the protein binding of drugs in animals and in manEuropean Journal of Clinical Pharmacology, 1977
- Protein binding of drugs in uremic and normal serum: The role of endogenous binding inhibitorsBiochemical Pharmacology, 1976