v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas.
- 1 February 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (4) , 1168-1172
- https://doi.org/10.1073/pnas.86.4.1168
Abstract
Cas NS-1 is an acutely transforming murine retrovirus that induces pre-B cell lymphomas. Molecular cloning showed it was generated from the ecotropic Cas-Br-M virus by sequential recombinations with endogenous retroviral sequences and a cellular oncogene. The oncogene sequence shows no homology with known oncogenes but some similarity to the yeast transcriptional activator GCN4. A 100-kDa gag-cbl fusion protein, with no detectable kinase activity, is responsible for the cellular transformation. The cellular homologue of v-cbl, present in mouse and human DNA, is expressed in a range of hemopoietic lineages.This publication has 52 references indexed in Scilit:
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