A novel property of a mitochondrial presequence
- 26 July 1993
- journal article
- Published by Wiley in FEBS Letters
- Vol. 327 (2) , 172-176
- https://doi.org/10.1016/0014-5793(93)80164-p
Abstract
A new property of the presequence of the mitochondrial precursor protein cytochrome oxidase subunit IV is presented. This mitochondrial presequence induces interbilayer contacts between large unilamellar vesicles consisting of phosphatidylcholine and cardiolipin. The presequence-vesicle aggregates can be dissociated by applying a membrane potential across the bilayers (negative inside). These effects require the presence of cardiolipin and are not observed for other negatively charged phospholipids. We propose a role for the presequence in the formation and dissociation of mitochondrial contact sites.Keywords
This publication has 59 references indexed in Scilit:
- Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potentialPublished by Elsevier ,2002
- A dynamic model of the mitochondrial protein import machineryCell, 1992
- Mitochondrial preproteins en route from the outer membrane to the inner membrane are exposed to the intermembrane spaceFEBS Letters, 1991
- Secondary structure of a mitochondrial signal peptide in lipid bilayer membranesFEBS Letters, 1990
- Modulation of membrane surface curvature by peptide-lipid interactionsBioscience Reports, 1988
- Interaction of melittin with negatively charged phospholipids: Consequences for lipid organizationFEBS Letters, 1987
- Polymorphic regulation of membrane lipid compositionNature, 1987
- Phosphodiester bond cleavage outside mitochondria is required for the completion of protein import into the mitochondrial matrixCell, 1987
- Incorporation of a synthetic mitochondrial signal peptide into charged and uncharged phospholipid monolayersBiochemistry, 1986
- Cytoplasmic type 80S ribosomes associated with yeast mitochondria. IV. Attachment of ribosomes to the outer membrane of isolated mitochondria.The Journal of cell biology, 1975