Synthesis and tissue distribution study of iodine-labeled benzyl- and xylylamines
- 1 July 1982
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 25 (7) , 870-873
- https://doi.org/10.1021/jm00349a022
Abstract
Four 125I-labeled mono- and diamines were prepared and evaluated as potential brain-imaging agents. The diamines are analogs of the previously reported 75Se-labeled diamines, which show high brain uptake and retention. All of the radioiodinated amines display high initial brain uptake in rats after i.v. injection (1.7-2.4% dose/organ). The xylylenediamines show prolonged brain retention (t1/2 [half-life] .apprxeq. 18 h), which is desirable for brain imaging. The benzylamine is rapidly cleared from brain tissue (T1/2 .apprxeq. 15 min).This publication has 5 references indexed in Scilit:
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