STUDIES ON ANTIBODY PRODUCTION

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Abstract
After injection of ovalbumin as a water-in-oil emulsion a pronounced adjuvant effect is demonstrable following the incorporation of tubercle bacillary wax into the oily phase of the mixture. With single doses of antigen (10 mg. ovalbumin) there is a 4- to 5-fold increase in the amount of antibody at the median of 3 week serum levels in animals receiving a small dose of wax (40 µg.). With a 5 mg. dose of wax there is an 8-fold increase in serum antibody levels at the median.