Inherited Polymorphism of Guinea Pig Factor B and C4: Evidence for Genetic Linkage between the C4 and Bf Loci
Open Access
- 1 May 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 118 (5) , 1822-1826
- https://doi.org/10.4049/jimmunol.118.5.1822
Abstract
An inherited structural polymorphism of the guinea pig complement protein C4 and of factor B of the alternative pathway was demonstrated by use of high voltage agarose electrophoresis combined with a subsequent immunofixation technique. No polymorphism of guinea pig C3 could be shown. Three common allelic genes were proven to code for C4-S, C4-Sl, and C4-F, respectively. Two common allelic genes are responsible for the Bf-F and Bf-S phenotype expression. A strong linkage disequilibrium between both C4 and Bf was demonstrated.This publication has 5 references indexed in Scilit:
- The chromosomal order of genes controlling the major histocompatibility complex, properdin factor B, and deficiency of the second component of complement.Journal of Clinical Investigation, 1976
- Inherited structural polymorphism in human C2: evidence for genetic linkage between C2 and Bf.The Journal of Experimental Medicine, 1976
- MOUSE FACTOR-B OF ALTERNATIVE PATHWAY OF COMPLEMENT ACTIVATION .1. PURIFICATION, CHARACTERIZATION, AND FUNCTIONAL BEHAVIOR1976
- Localization of the Bf locus within the HLA regionHuman Genetics, 1976
- A SEROLOGICALLY DETECTED VARIANT IN MOUSE SERUM: INHERITANCE AND ASSOCIATION WITH THE HISTOCOMPATIBILITY-2 LOCUSGenetics, 1963