TRANSPLANTATION OF HUMAN RENAL CARCINOMAS INTO ATHYMIC MICE

  • 1 January 1985
    • journal article
    • research article
    • Vol. 45  (6) , 2650-2653
Abstract
Thirty-one primary human renal carcinomas were transplanted into athymic mice of which 10 produced tumors in the mouse host. Only tumors with a nuclear grade of 3 or 4 were successfully transplanted. The nuclear grades of the human tumor and transplant were similar; however, the cellular histology often varied. Patient prognosis appeared to be inversely related to successful tumor transplantation. In the transplant group, the 1-yr survival was 30% in contrast to a 1-yr survival of 83% among patients with renal cancers of similar stage and grade which did not produce tumors in the mice. [The use of this technique to identify surgically treated patients with an unfavorable prognosis was described.].