Mechanism of Adrenal Atrophy in Cushing's Syndrome Due to Adrenal Tumor

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Abstract
ATROPHY of the contralateral adrenal gland is a characteristic feature of Cushing's syndrome due to an adrenal tumor. Numerous studies, beginning with those of Ingle and Kendall,1 have shown this to be the result of pituitary suppression by the excessive corticoid hormones secreted by the tumor, with consequent inhibition of ACTH production or release. Before the development of effective replacement therapy this complication, for which Selye2 suggested the term compensatory atrophy, resulted in a formidable mortality after removal of the tumor. Available therapy now facilitates survival, thus providing the opportunity to study the mechanism of compensatory adrenal atrophy and to . . .