THE INACTIVATION OF INFLUENZA VIRUSES BY TANNIC ACID AND RELATED COMPOUNDS

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Abstract
The inactivation of PR8 influenza virus by neutralized and filtered tannic and digallic acids was demonstrated. The dose of both was approx. 0.001 mg. in vitro and 0.5 mg. in vivo for 100 LD50 of virus. Gallic, pyrogallic, and gentisic acids showed slight to no inhibition. With tannic acid, inactivation was obtained when the drug was admd. up to 96 hrs. prior to and 1 hr. after injn. of virus. A no. of crude tannins also were tested, and of these valonia, mangrove, chestnut, hemlock, myrabolan, and wattle extracts inactivated the virus in vivo.