The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis
Top Cited Papers
Open Access
- 12 November 2004
- journal article
- review article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 95 (10) , 957-970
- https://doi.org/10.1161/01.res.0000148632.35500.d9
Abstract
Apoptosis has been causally linked to the pathogenesis of myocardial infarction and heart failure in rodent models. This death process is mediated by two central pathways, an extrinsic pathway involving cell surface receptors and an intrinsic pathway using mitochondria and the endoplasmic reticulum. Each of these pathways has been implicated in myocardial pathology. In this review, we summarize recent advances in the understanding of the intrinsic pathway and how it relates to cardiac myocyte death and heart disease.Keywords
This publication has 194 references indexed in Scilit:
- Inhibition of Both the Extrinsic and Intrinsic Death Pathways through Nonhomotypic Death-Fold InteractionsMolecular Cell, 2004
- Disruption of Mitochondrial Function during Apoptosis Is Mediated by Caspase Cleavage of the p75 Subunit of Complex I of the Electron Transport ChainCell, 2004
- Cell Death: Critical Control PointsPublished by Elsevier ,2004
- “Recruitment Signals” from Apoptotic CellsCell, 2003
- Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1Cell Death & Differentiation, 1999
- Crystal structure of apaf-1 caspase recruitment domain: an α-helical greek key fold for apoptotic signaling 1 1Edited by D. C. ReesJournal of Molecular Biology, 1999
- Bcl-xL forms an ion channel in synthetic lipid membranesNature, 1997
- Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell deathCell, 1993
- bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell deathCell, 1993
- Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 1985