THE EFFECT OF SODIUM-RETAINING CORTICOID, ELECTROCORTIN, DESOXYCORTICOSTERONE, AND CORTISONE ON RENAL FUNCTION AND EXCRETION OF SODIUM AND WATER IN ADRENALECTOMIZED RATS

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Abstract
Under the conditions used in the bioassay of Na-retaining activity, adrenalectomized rats showed subnormal glomerular filtration rate, impaired diuresis, and loss of Na in the urine with reduced serum Na concentration. Cortisone (100 [mu]g) increased creatinine output and diuresis, but failed to reduce Na loss. DCA (10 [mu]g) increased creatinine output and reduced Na loss; but urine flow was decreased. Na-retaining hormone from urine and from adrenal cortex(Electrocortin), in doses of a fraction of a micro-gram reduced Na loss without affecting glomerular filtration rate or diuresis. These Na-retaining hormones appear to affect primarily the reabsorption of Na by the renal tubules.