In Vitro Leishmanicidal Activity of a Monoclonal Antibody mimicking a Yeast Killer Toxin

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Abstract
The microbicidal effect of a monoclonal antiidiotypic antibody, mimicking the activity of a yeast killer toxin, characterized by a wide antimicrobial spectrum, has been evaluated in vitro against two relevant species of protozoan parasites, Leishmania major and Leishmania infantum. The antiidiotypic antibody exerted a significant and dose‐dependent antileishmanial activity against parasite promastigotes in comparison to an irrelevant isotype‐matched monoclonal antibody. This is the first demonstration that an antibody, which had been already shown to be fungicidal and bactericidal, may also exert a direct microbicidal activity against protozoa.