Changing Patterns in HIV Reverse Transcriptase Resistance Mutations after Availability of Tenofovir
Open Access
- 1 June 2008
- journal article
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 46 (11) , 1782-1785
- https://doi.org/10.1086/588045
Abstract
Assessment of 1177 human immunodeficiency virus (HIV) resistance genotypes at an HIV/AIDS clinic showed a decrease in the incidence of the K65R mutation, from 15.2% of isolates during the period 2002–2004 to 2.7% of isolates during the period 2005–2006 (P<.001), despite elevated and stable rates of tenofovir use. A reduction in the rate of coadministration of didanosine (from 41.6% of patients in 2004 to 0.8% of patients in 2006; P<.001) largely explained this observation.Keywords
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