Role of Baseline Human Immunodeficiency Virus Genotype as a Predictor of Viral Response to Tenofovir in Heavily Pretreated Patients
- 1 September 2003
- journal article
- research article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 41 (9) , 4421-4423
- https://doi.org/10.1128/jcm.41.9.4421-4423.2003
Abstract
Human immunodeficiency virus (HIV)-infected patients ( n = 153) failing antiretroviral therapy after exposure to compounds from all three drug families were monitored for 6 months after beginning a rescue intervention program including tenofovir (TDF). At 3 months, levels of HIV RNA in plasma dropped by a mean of 0.9 log 10 and the mean CD4 count increased by 52 cells/μl. At 6 months, HIV RNA levels had dropped by a mean of 1.06 log 10 and the mean CD4 count had increased by 49 cells/μl. Only five (3.7%) patients discontinued TDF use due to adverse events. In the multivariate analysis, the presence of M41L and/or L210W at baseline was the only viral determinant of a lower response to TDF.Keywords
This publication has 4 references indexed in Scilit:
- Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DFAIDS, 2002
- Tenofovir DF in antiretroviral-experienced patients: results from a 48-week, randomized, double-blind studyAIDS, 2002
- Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral TherapyA Randomized Controlled TrialJAMA, 1999
- Human Immunodeficiency Virus Type 1 Expressing the Lamivudine‐Associated M184V Mutation in Reverse Transcriptase Shows Increased Susceptibility to Adefovir and Decreased Replication Capability In VitroThe Journal of Infectious Diseases, 1999