Inhibition of clinically significant bacterial organisms in vitro by 2-acetylpyridine thiosemicarbazones

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Abstract
Antibacterial activity of 65 2-acetylpyridine thiosemicarbazones and related compounds was determined by using clinical isolates of 9 bacterial genera. Minimal inhibitory concentrations (MIC) of 0.002-0.062 .mu.g/ml were obtained with 23% of the compounds for Neisseria gonorrhoeae and 0.016-0.062 .mu.g/ml with 17% of the compounds for N. meningitidis. Staphylococcus aureus was inhibited in the MIC range of 0.125-0.5 .mu.g/ml by 18% of the thiosemicarbazones, whereas 26% inhibited group D enterococcus with an MIC of 0.25-2.0 .mu.g/ml. Poor antibacterial activity was shown toward the gram-negative bacilli, i.e., Pseudomonas, Klebsiella-Enterobacter, Shigella, Escherichia coli and Proteus.