STUDIES ON BLOOD COAGULATION: THE NATURE AND PROPERTIES OF A PROTEOLYTIC ENZYME DERIVED FROM PLASMA 123

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Abstract
The following data gave chemical evidence of the enzyme nature of the globulin fraction of plasma after treatment with chloroform: The increase of protein split products in the reaction mixture under sterile conditions using fibrinogen, fibrin, casein and gelatin as substrates; the decrease in the viscosity of gelatin solns., the dependence of velocity of reaction on pH, the optimal pH of 7.4; the dependence of reaction velocity on temp., the optimal temp. of 37.5[degree] C. and the Q.10 for 20-30[degree] C. 1.5; and the obedience of the reaction kinetics to the emplrical equations such as Shutz law.