ANKYLOSING-SPONDYLITIS, HLA-B27 AND KLEBSIELLA .1. CROSS-REACTIVITY STUDIES WITH RABBIT ANTISERA
- 1 January 1980
- journal article
- research article
- Vol. 61 (1) , 85-91
Abstract
Sera from rabbits immunized with HLA-B27 lymphocytes showed increased activity against Klebsiella enterobacterial antigens using immunodiffusion, bacterial agglutination (P < 0.025), hemagglutination (P < 0.001) and radiobinding assays (P < 0.001). Immunoprecipitin lines were produced by these anti-lymphocyte sera against extracts from Yersinia enterocolitica and Shigella sonnci microorganisms. Rabbit anti-Klebsiella sera had lymphocytotoxic activity against HLA-B27 lymphocytes obtained from patients with ankylosing spondylitis (P < 0.001). Partial cross-reactivity may exist between some antigens found in several gram-negative microorganisms and HLA-B27 lymphocytes.This publication has 11 references indexed in Scilit:
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