Nicorandil attenuates myocardial acidosis during coronary occlusion in dogs

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Abstract
1 In dogs anaesthetized with pentobarbitone, the left anterior descending coronary artery (LAD) was partially occluded. Before and 30 min after partial occlusion, the myocardial pH was 7.52–7.54 and 6.89–6.91, respectively. 2 Nicorandil (50 μg kg−1, i.v.) increased the pH that had been reduced by partial occlusion and this effect lasted at least 60 min. Thus nicorandil attenuates ischaemic myocardial acidosis.