THE METABOLISM OF DEHYDROEPIANDROSTERONE IN VARIOUS ORGANS OF THE RAT
- 1 September 1965
- journal article
- research article
- Published by Oxford University Press (OUP) in Acta Endocrinologica
- Vol. 50 (1) , 123-130
- https://doi.org/10.1530/acta.0.0500123
Abstract
Ten minutes after the intra-peritoneal injection of dehydroepiandrosterone-7[alpha]-H3 into a 45 day old male rat, testosterone was detected only in the testes as the primary metabolite. Aetiocholan-3[alpha]-ol-17-one was found in the liver, seminal vesicles and kidneys and unidentified polar compounds were found in all the organs investigated. No androst-4-ene-3,17-dione was detected in any of the organs as a metabolite of dehydroepiandrosterone and no testosterone in the testes following the injection of 4-C14-androst-4-ene-3,17-dione. The possible mechanism of the conversion of dehydroepiandrosterone to testosterone is discussed.This publication has 5 references indexed in Scilit:
- THE INITIAL METABOLISM OF 4-14C-TESTOSTERONE IN THE RAT. II.Acta Endocrinologica, 1964
- Formation of Dehydroepiandrosterone Duringin Vivoandin VitroBiosynthesis of Testosterone by Testicular TissueEndocrinology, 1964
- ISOLIERUNG VON DEHYDROEPIANDROSTERON AUS MENSCHLICHEM SPERMAActa Endocrinologica, 1963
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