Metabolism of 17β-Estradiol and Estrone by Human Proliferative Endometrium and Myometrium1

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Abstract
In vitro incubation of human endometrium and myometrium has demonstrated both tissues to transform 17β-estradiol to estrone. The capacity of endometrium is approximately 40 times that of myometrium. The reverse reaction is of a much lower magnitude, indicting the biotransformation is in favor of the formation of estrone. The capacity of endometrium appears sufficient to oxidize essentially all ovarian synthesized estradiol, normally reaching it via the blood stream. It is suggested that this capacity is of sufficient magnitude to necessitate consideration of the possible association of hormonal action with chemical change. (Endocrinology81: 167, 1967)