Circulating Endothelial Progenitors — Cells as Biomarkers

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Abstract
Endothelial injury and dysfunction are thought to be critical events in the pathogenesis of atherosclerosis. Thus, understanding the mechanisms that maintain and restore endothelial function may have important clinical implications. A series of clinical and basic studies prompted by the discovery of bone marrow–derived endothelial progenitor cells1 have provided insights into these processes and opened a door to the development of new therapeutic approaches.Growing evidence suggests that bone marrow–derived endothelial progenitor cells circulate in the blood and play an important role in the formation of new blood vessels as well as contribute to vascular homeostasis in the adult. Circulating . . .