CHANGES IN LABELING OF SOLUBLE AND SOLUBILIZED HIPPOCAMPUS PROTEINS AFTER A LEARNING EXPERIMENT IN RATS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 35  (2) , 213-219
Abstract
At various intervals after acquisition of a brightness discrimination in rats labeled leucine was intraventricularly applied. Hippocampus tissue was fractionated in soluble and solubilized insoluble protein fractions. Protein content and labeling of several electrophoretically resolved bands showed a biphasic time course: a 1st increase was observed 20 min after training including preferably soluble proteins, whereas a 2nd increase (about 8 h after training) was mainly related to solubilized insoluble proteins.