Partition and distribution coefficients of aryloxypropanolamine β-adrenoceptor antagonists
- 1 January 1992
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 44 (1) , 68-70
- https://doi.org/10.1111/j.2042-7158.1992.tb14369.x
Abstract
N-Octanol/water partition and distribution coefficients of fifteen β-blockers have been measured and the relationships between log P (neutral species), log Pi (fully ionized species) and log D7·4 have been examined. A strict correlation exists among these three parameters, suggesting that the ionization exerts similar effects on the partition behaviour of these drugs.Keywords
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