Human retinoblastoma cells express αB-crystallinin vivoandin vitro
- 1 January 1993
- journal article
- case report
- Published by Taylor & Francis in Current Eye Research
- Vol. 12 (3) , 239-245
- https://doi.org/10.3109/02713689308999469
Abstract
Alpha B-crystallin is a major lens protein that is a member of the heat-shock family of proteins. Using immunohistochemical and northern blot techniques, we now demonstrate its presence in freshly-fixed retinoblastoma tissue. The protein is also abundantly expressed in cultured human retinoblastoma cells (Y-79 NEI, WERI Rb-1) as well as two subcultured Y-79 lines (ATCC and GM01232C). High expression of alpha B-crystallin may be involved in tumor growth and/or be a marker for general oncogenic "stress" in the tumor tissue.Keywords
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