Transcriptional induction of cellular gene expression during lytic infection with herpes simplex virus
- 1 November 1986
- journal article
- conference paper
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 6 (11) , 945-951
- https://doi.org/10.1007/bf01114970
Abstract
Herpes simplex virus Type 2 causes a severe repression of host cell biosynthesis at a number of levels. We show that despite this, non-viral cDNA clones derived from cellular RNA species which accumulate to high levels after infection can be isolated using differential screening techniques. By using nuclear run-off assays, we have shown that this RNA accumulation is mediated by transcriptional induction of the corresponding cellular genes.This publication has 20 references indexed in Scilit:
- Hybridization of herpes simplex virus dna and human ribosomal DNA and RNAVirology, 1985
- Activation of a Qa/Tla class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouseNature, 1983
- A technique for radiolabeling DNA restriction endonuclease fragments to high specific activityAnalytical Biochemistry, 1983
- The oncogenic potential of herpes simplex viruses: evidence for a ‘hit-and-run’ mechanismNature, 1983
- Inhibition of Host Protein Synthesis and Degradation of Cellular mRNAs During Infection by Influenza and Herpes Simplex VirusMolecular and Cellular Biology, 1982
- The isolation of cloned cDNA sequen which are differentially expressed in human lymphocytes and fibroblastsNucleic Acids Research, 1980
- [68] Transcription maps of polyoma virus-specific RNA: Analysis by two-dimensional nuclease S1 gel mappingPublished by Elsevier ,1980
- Suppression of the Synthesis of Cellular Macromolecules by Herpes Simplex VirusJournal of General Virology, 1978
- Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituScience, 1977
- Recovery of Herpes-Simplex Virus from Human Trigeminal GanglionsNew England Journal of Medicine, 1973