Synovial Membrane in Traumatic Effusion

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Abstract
Synovial biopsies from 4 normal subjects and 18 patients with traumatic joint effusion were studied with histochemical, electron-microscopic and autoradiographic techniques. Ribonucleic acid-(RNA)- positive synovial cells were more frequent and their numbers and the intensity of their staining reaction showed a significant increase with increase in the volume of synovial fluid with effusion. Electron micrographs of synovium from joints with effusion showed a marked increase in synovial cells containing rough endoplasmic retlculum and Palade granules. These features correlated with the heavy uptake of H3-leucine by synovial cells after in-vitro incubation and autoradiography. Some of the excess protein in synovial fluid in traumatic effusion may be contributed by the synovial cells.