Nature of Hyperacute (Accelerated Second Set) Rejection in Dog Renal Allographs and Effects of Heparin on Rejection Process

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Abstract
Renal allografts were exchanged between unrelated mongrel dogs after previous sensitization with skin and kidney grafts from the same donors. Rapid rejection of the renal allografts was associated with the accumulation of platelets and leucocytes in the peritubular and glomerular capillaries but fibrin deposition was not demonstrated. Heparin infusion delayed but did not prevent the rejection process.