INCREASED FREQUENCY OF B8-DR3 IN SCLERODERMA AND ASSOCIATION OF THE HAPLOTYPE WITH IMPAIRED CELLULAR IMMUNE-RESPONSE
- 1 January 1981
- journal article
- research article
- Vol. 43 (3) , 478-485
Abstract
Patients with scleroderma (28) were typed for 40 HLA antigens. A highly significant increase in the frequency of HLA-B8 and HLA-DR3 was observed, which was not related to disease severity. In vitro lymphocyte stimulation tests were performed in 26 patients. Humoral and in vitro cellular immune responses to a primary test antigen were measured in 12 of them. Although the scleroderma patient group as a whole had an impaired cellular response, only the B8/DR3+ patients had a strongly depressed response; the immune response of the others was normal. An association of the haplotyped B8/DR3 with impaired cellular immunity is suggested.This publication has 26 references indexed in Scilit:
- HLA‐B8 in Raynaud's PhenomenonTissue Antigens, 1980
- Immunoregulatory circuits among T-cell sets. II. Physiologic role of feedback inhibition in vivo: absence in NZB mice.The Journal of Experimental Medicine, 1978
- Association of HLA Antigen A9 with Progressive Systemic Sclerosis (Scleroderma)Tissue Antigens, 1978
- In Vitro Immune Responsiveness to Vaccinia Virus and HLANew England Journal of Medicine, 1977
- HL‐A antigens in progressive systemetic sclerosis (scleroderma)Arthritis & Rheumatism, 1975
- Immunoglobulin synthesis by peripheral blood cells in systemic lupus erythematosusArthritis & Rheumatism, 1975
- URACIL-SPECIFIC ANTI-R.N.A. ANTIBODIES IN SCLERODERMAThe Lancet, 1975
- Some Contributions of the HL-A Complex to the Genetics of Human DiseasesImmunological Reviews, 1975
- Altered immunoglobulin metabolism in systemic lupus erythematosus and rheumatoid arthritisJournal of Clinical Investigation, 1970
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955