Carrageenin-induced arthritis.1. The effect of intraarticular carrageenin on the chemical composition of articular cartilage

Publisher Website
Google Scholar
Abstract
A single intraarticular injection of carrageenin into rabbit knee joints initiated a localized synovial inflammatory response. This response was accompanied by a 20% loss of proteoglycan from the articular cartilage within 24 hours and by a further 30–60% loss within 5–7 days. The chondrocytes replaced the lost proteoglycan within 42 days. More than two injections caused only a further small decrease in proteoglycan content; the cartilage was then unable to replace the lost proteoglycan. The absence of recovery coincided with the appearance of erosion of the cartilage surface.

This publication has 28 references indexed in Scilit: