Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy
- 13 March 2002
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 67 (1) , 88-91
- https://doi.org/10.1002/jmv.2195
Abstract
Sequential herpes simplex virus (HSV) isolates from AIDS patients receiving foscarnet therapy were evaluated for susceptibility to adefovir. Foscarnet-resistant isolates with DNA polymerase mutations in regions II, VI, and between I and VII were also associated with an important decrease in susceptibility to adefovir (mean IC50 increase: 4.6-fold compared to pre-foscarnet or wild-type isolates) suggesting that adefovir-resistant HSV could be selected in vivo by foscarnet therapy. J. Med. Virol. 67:88–91, 2002.Keywords
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