Sputum Itraconazole Concentrations in Cystic Fibrosis Patients
Open Access
- 1 June 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (6) , 1937-1938
- https://doi.org/10.1128/aac.45.6.1937-1938.2001
Abstract
Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range.Keywords
This publication has 14 references indexed in Scilit:
- Allergic Bronchopulmonary Aspergillosis in Cystic FibrosisChest, 1999
- Drug Disposition in Cystic FibrosisClinical Pharmacokinetics, 1998
- In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosisAntimicrobial Agents and Chemotherapy, 1997
- Prevalence of Allergic Bronchopulmonary Aspergillosis and Atopy in Adult Patients With Cystic FibrosisChest, 1996
- Itraconazole and allergic bronchopulmonary aspergillosis in twin brothers with cystic fibrosisThe Lancet, 1993
- Adjunctive Therapy of Allergic Bronchopulmonary Aspergillosis with ItraconazoleChest, 1991
- Antifungal Prophylaxis with Itraconazole in Prolonged Neutropenia: Correlation with Plasma LevelsMycoses, 1989
- Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivoBiochemical Pharmacology, 1986
- Allergic Bronchopulmonary AspergillosisArchives of internal medicine (1960), 1983