Serotonin Transporter Genotype and Acute Subjective Response to Amphetamine
- 10 September 2006
- journal article
- research article
- Published by Wiley in The American Journal on Addictions
- Vol. 15 (5) , 327-335
- https://doi.org/10.1080/10550490600859868
Abstract
The authors have previously shown an effect of dopamine transporter genotype on acute subjective responses to d‐amphetamine, which may affect risk of addiction. They now report the results of an evaluation of the role of the serotonin transporter gene (HTT) using a double‐blind, placebo‐controlled, crossover design in which subjects (N = 101) completed self‐report measures of subjective effect. The separate and combined analyses of the gene‐linked polymorphic region (5‐HTTLPR) and the Intron 2 VNTR suggest that these two HTT polymorphisms may contribute to acute subjective responses to d‐amphetamine with a small effect.Keywords
This publication has 60 references indexed in Scilit:
- ADH1B*1, ADH1C*2, DRD2 (−141C Ins), and 5‐HTTLPR Are Associated With Alcoholism in Mexican American Men Living in Los AngelesAlcohol, Clinical and Experimental Research, 2004
- Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expressionBiological Psychiatry, 2004
- The common variants/multiple disease hypothesis of common complex genetic disordersMedical Hypotheses, 2004
- Variations in affect following amphetamine and placebo: Markers of stimulant drug preference.Experimental and Clinical Psychopharmacology, 2003
- Variations in affect following amphetamine and placebo: Markers of stimulant drug preference.Experimental and Clinical Psychopharmacology, 2003
- Serotonin Transporter Genetic Variation and the Response of the Human AmygdalaScience, 2002
- Association Mapping in Structured PopulationsAmerican Journal of Human Genetics, 2000
- Population studies of polymorphisms of the serotonin transporter protein geneAmerican Journal of Medical Genetics, 1999
- Allelic Variation of Human Serotonin Transporter Gene ExpressionJournal of Neurochemistry, 1996
- Synaptic organization of serotonin‐immunoreactive fibers in primary visual cortex of the macaque monkeyJournal of Comparative Neurology, 1988