METABOLISM OF DIMETHYLNITROSAMINE AND 1,2-DIMETHYLHYDRAZINE IN CULTURED HUMAN BRONCHI
- 1 January 1977
- journal article
- research article
- Vol. 37 (7) , 2309-2311
Abstract
The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies showed that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine also bound to cellular DNA and protein. Bronchial DNA was methylated in the 0-6 and N-7 positions of guanine. In addition to polynuclear aromatic hydrocarbons, an aliphatic nitrosamine and a methylhydrazine can now be added to the list of xenobiotic chemical carcinogens metabolized by human bronchus.This publication has 8 references indexed in Scilit:
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