Effect of Two Recently Developed Antiseptics on Dental Plaque and Caries in Rats

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Abstract
This investigation measured the effect of two agents: CK 0569 A (a piperazine derivative) and octenidine on dental caries and plaque when used as oral rinses in rats. Twice daily flushings with aqueous solutions of either agent (0.5%) provided significant protection against dental caries and plaque, similar to that provided by chlorhexidine, when compared to the effects of the placebo rinses. However, when flushings (1.0%) were provided only once daily, only the octenidine-treated group exhibited a mean caries score that was significantly lower than that in the placebo-treated group. Animals receiving oral flushings once daily with octenidine (1.0%) in an oral flushing vehicle exhibited a 37% numerical decrease (0.1 > p > 0.05) in plaque scores compared with the animals treated with the carrier solution without additive.