Patterns of Failure and Outcome in Esthesioneuroblastoma

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Abstract
ESTHESIONEUROBLASTOMA (ENB) is an uncommon malignant tumor originating from the olfactory neuroepithelium of the upper nasal vault first described by Berger and Luc1 in 1924. This tumor constitutes 3% of all intranasal neoplasms and can be seen in all ages, with a peak in the second and sixth decades of life and with equal distribution between the sexes.2,3 As a result of its anatomic origin high in the nasal cavity, most patients have nonspecific symptoms, precluding early diagnosis and leading to the development of locally advanced disease that involves the paranasal sinuses and anterior cranial fossa through the cribriform plate in a large number of patients.