MICRURGICAL STUDIES IN CELL PHYSIOLOGY

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Abstract
The quiescence, rounding, sinking of the granules, and paling of the nucleus are similar to the effects seen after the injection of potassium and sodium chloride (11). Since the sodium salts of the anions were used, it might be inferred that the sodium is the active agent in the injected solutions. This is not entirely the case, however, for the effective concentrations of NaCl required are many times greater than those required in the case of the sodium salts of the calcium-precipitating anions. The fact that practically the same effects can be obtained in both cases leads one to suspect that there is a relation between the results of an increase in sodium ions and a decrease in calcium ions. It has been shown that a M/416 CaCl2 solution will antagonize a M/1 NaCl solution and even a more concentrated solution of KCl inside the ameba (12). Therefore the reduction in amount of calcium may leave a comparatively high concentration of unantagonized sodium and potassium.

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