CIRCULIN AN ANTIBIOTIC FROM AN ORGANISM RESEMBLING BACILLUS CIRCULANS

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Abstract
The discovery of circulin, an antibiotic from an organism closely resembling Bacillus circulans, is descr. This inhibits the growth of Gram-negative bacteria more strongly than that of Gram-positive bacteria. Its bacterial spectrum differs from that of polymyxin and aerosporin. Circulin is inactivated by crude trypsin, whereas polymyxin is not. The procedures involved in the production of circulin and the general properties of a relatively pure prepn. are descr. Circulin appears to be somewhat less toxic than aerosporin but more toxic than polymyxin.
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