Circulin, an Antibiotic from a Member of the Bacillus circulans Group

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Abstract
An antibiotic, named circulin, has been obtained from broth cultures of a mucoid variant of B. circulans. This antibiotic is active against Gram-positiveand Gram-negative bacteria, Myco-bacterium tuberculosis (H37Rv) and fungi, and its action is both bacteriostatic and bactericidal. The crystalline material, a poly-peptide, is very stable in dilute HC1 and is resistant to autoclaving in acid or neutral soln. The purified material is hemolytic for human, rabbit, sheep, and mouse cells, and is extremely toxic for mice. Attempts to neutralize the hemolytic activity have not succeeded.