Failure of Intravenous Aspirin to Increase Gastrointestinal Blood Loss
- 9 August 1969
- Vol. 3 (5666) , 330-332
- https://doi.org/10.1136/bmj.3.5666.330
Abstract
Studies of the effect of intravenous sodium acetylsalicylate (aspirin) on gastrointestinal blood loss with 51Cr-labelled red cells were made on 15 healthy male volunteers. After a control period of five days 1 g. of sodium acetylsalicylate was infused over a period of 100 minutes twice daily for three days. Faecal blood loss was not increased. In a further six subjects 3 g. of sodium acetylsalicylate was infused over a period of 120 minutes. No salicylate or acetylsalicylate was detected in saliva or gastric washings from these six subjects. Hence gastrointestinal blood loss induced by aspirin may be explained by a local effect on mucosa and not by any systemic effect.Keywords
This publication has 10 references indexed in Scilit:
- Alcohol, Aspirin, and Gastrointestinal BleedingBMJ, 1968
- The effect of salicylates on the hemostatic properties of platelets in manJournal of Clinical Investigation, 1968
- Effect of five salicylate-containing compounds upon loss of 51chromium-labelled erythrocytes from the gastrointestinal tract of normal man.Gut, 1968
- Role of Gastric Acid in Aspirin-Induced Gastric Irritation in the RatGastroenterology, 1967
- Gastric hemorrhage induced by nonnarcotic analgetic agents in dogsClinical Pharmacology & Therapeutics, 1966
- Effect of paracetamol (N-acetyl-p-aminophenol) on gastrointestinal bleedingGut, 1964
- Effect of aspirin on gastric secretionGut, 1964
- The Effect of Salicylates upon the Stomachs of DogsGastroenterology, 1964
- Fecal Blood Loss Produced by Oral and Intravenous Administration of Various SalicylatesGastroenterology, 1961
- Rapid determination of salicylate in biological fluidsBiochemical Journal, 1954