Inhibition of the acrosome reaction of sea urchin spermatozoa by a calmodulin antagonist, N‐(6‐aminohexyl)‐5‐chloro‐1‐naphthalenesulfonamide (W‐7)

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Abstract
A calmodulin antagonist, W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide), inhibited induction of the acrosome reaction of sea urchin spermatozoa by egg jelly at 20–50 μM, but W-5 did not. The latter, a chlorine-deficient derivative of W-7, has a lower affinity for calmodulin than does W-7. These results suggest that a Ca2+ -calmodulin-dependent process plays an important role in the triggering process of the acrosome reaction of Sea urchin spermatozoa.