Effect of Food Administration on Lipogenesis in Normal and Adrenalectomized Rats

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Abstract
Normal and adrenalectomized rats were either force fed or allowed to eat ad libitum a high carbohydrate diet for 3–4 weeks. The food intake of the force-fed groups was adjusted so that the rate of weight gain of the normal animals was equal to that of normal rats eating ad libitum. During the last 2 days of life, C14-labeled sodium acetate was included in the diet and its rate of incorporation into body fat was measured. The results reveal that under these conditions, the force-fed adrenalectomized rat gained weight at the same rate as normal force-fed controls. Furthermore, the adrenal steroid deficient animal fed in this manner contained amounts of body fat and incorporated C14 into the lipid moiety in quantities that did not differ from those of force-fed normal rats. By contrast, the adrenalectomized rat eating ad libitum gained less weight, contained less body fat but incorporated more C14 into his fat fraction than normal controls. We conclude that in the well nourished state, no deviation from normal in lipogenesis exists in the animal lacking his adrenal glands.