Lethal interactions of theeye-goneandeyelessmutants inDrosophila melanogaster

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Abstract
SUMMARY: A synthetic lethal system involving homozygous combination of the non-allelic eye mutantseye-goneandeyelessis described. The major lethal crisis is towards the end of the pupal instar although a number of double homozygotes die at pupation. The pupal lethal crisis can be overcome in a number of individuals by the experimental removal of the operculum from differentiated pupae. However, only a few of the resulting enclosed double homozygotes proved fully viable, the remainder dying almost immediately after emergence. Dissection of the surviving adults revealed that the brain is located in the anterior thorax.